| BIIK-Kazygurt |  | 3-1 |  | Verona |
| Referee: Eszter Urban (HUN) – Stadium: BIIK Stadium, Shymkent (KAZ) | ||||
| Medyk Konin |  | 4-3 |  | Brescia |
| Referee: Petra Chudá (SVK) – Stadium: Miejski Im. Złotej Jedenastki, Konin (POL) | ||||
| Sarajevo |  | 0-0 |  | Rossiyanka |
| Referee: Lois Otte (BEL) – Stadium: Asim Ferhatović Hase Stadion, Sarajevo (BIH) | ||||
| Breidablik |  | 0-1 |  | Rosengård |
| Referee: Sofia Karagiorgi (CYP) – Stadium: Kópavogsvöllur, Kopavogur (ISL) | ||||
| Sturm |  | 0-6 |  | Zürich |
| Referee: Jana Adámková (CZE) – Stadium: Stadion Graz Liebenau, Graz (AUT) | ||||
| Avaldsnes |  | 2-5 |  | Lyon |
| Referee: Teodora Albon (ROU) – Stadium: Haugesund, Haugesund (NOR) | ||||
| Apollon |  | 1-1 |  | Slavia Praha |
| Referee: Elvira Nurmustafina (KAZ) – Stadium: Paphiakos Stadium, Paphos (CYP) | ||||
| Twente |  | 2-0 |  | Sparta Praha |
| Referee: Marta Huerta De Aza (ESP) – Stadium: FC Twente Stadion, Enschede (NED) | ||||
| Athletic |  | 2-1 |  | Fortuna |
| Referee: Cristina Dorcioman (ROU) – Stadium: Estadio de San Mamés, Bilbao (ESP) | ||||
| Chelsea |  | 0-3 |  | Wolfsburg |
| Referee: Efthalia Mitsi (GRE) – Stadium: Stamford Bridge, London (ENG) | ||||
| SKN St.Pölten |  | 0-2 |  | Brøndby |
| Referee: Pernilla Larsson (SWE) – Stadium: NV Arena, St Polten (AUT) | ||||
| Hibernian |  | 0-6 |  | Bayern |
| Referee: Esther Staubli (SUI) – Stadium: Easter Road Stadium, Edinburgh (SCO) | ||||