Round of 16 : 31 October 2012
| Zorkiy |  | 0-9 |  | Lyon | |||||||||||||||
| Referee: Kirsi Heikkinen (FIN) – Stadium: Rodina, Moscow (RUS) | |||||||||||||||||||
| Stabæk |  | 0-0 |  | Juvisy | |||||||||||||||
| Referee: Natalia Avdonchenko (RUS) – Stadium: Nadderud, Oslo (NOR) | |||||||||||||||||||
| Fortuna |  | 1-1 |  | Göteborg | |||||||||||||||
| Referee: Kateryna Monzul (UKR) – Stadium: Hjørring Stadion, Hjorring (DEN) | |||||||||||||||||||
| Malmö |  | 1-0 |  | Verona | |||||||||||||||
| Referee: Alexandra Ihringova (ENG) – Stadium: Malmö Idrottsplats, Malmo (SWE) | |||||||||||||||||||
| Torres |  | 4-1 |  | Olimpia Cluj | |||||||||||||||
| Referee: Christine Baitinger (GER) – Stadium: Vanni Sanna, Sassari (ITA) | |||||||||||||||||||
Round of 16 : 1 November 2012
| Sparta Praha |  | 0-1 |  | Rossiyanka |
| Referee: Christina Westrum Pedersen (NOR) – Stadium: Bohemians Praha, Prague (CZE) | ||||
| Arsenal |  | 2-1 |  | Potsdam |
| Referee: Esther Azzopardi (MLT) – Stadium: Meadow Park, Borehamwood (ENG) | ||||
| Wolfsburg |  | 4-1 |  | Røa |
| Referee: Jana Adámková (CZE) – Stadium: VfL-Stadion, Wolfsburg (GER) | ||||
